Autosomal Lethal Mutation Frequencies in Drosophila

Effects of Some Autosomal Inversions on Lethal Mutation in Drosophila Melanogaster.

ITH the development of genetics, it has become implicit in the principle of segregation that the purity of segregating alleles or homologous chromosomes is subject to exception only where mechanisms of recombination are concerned. Recently, cases of apparent interallelic mod'fication have been described where thorough analysis has precluded the possibility of a basis in any recognized mechanism...

Genetics: Plough and Child a Utosomal Lethal Mutation Frequencies in Drosophila

Lethal mutation rate in Drosophila treated with 20-methylcholanthrene.

Tumors in Drosophila are in many ways similar to atypical growths in mammals, although they are dissimilar in others (6). A frequent question concerning these tumors is whether carcinogens alter their incidence. This has been tested by treat ing a tumor stock of Drosophila with 20-methylcholanthrene and is reported at this time. In a previous study (4) it was shown that the lethal mutation rate...

Sterility, chromosome breakage, x-ray induced mutation rates and detected mutation frequencies in Drosophila melanogaster.

AMONG the enduring problems of radiation genetics is the quantitative evaluation of mutational damage elicited in germ cells that have been exposed to a given dose of radiation. The significant question at issue is what proportion of all irradiated germ cells actually suffer an induced mutation, i.e., what is the mutation rate? This is the question that must be accurately answered before the co...

Cartilage matrix deficiency (cmd): a new autosomal recessive lethal mutation in the mouse.

A new autosomal recessive lethal mutation in the mouse designated cartilage matrix deficiency (cmd) is described. Homozygotes are dwarfed, and have abnormally short trunk, limbs, tail and snout, as well as a protruding tongue and cleft palate. The abdomen is distended because the foreshortened rib cage and spinal column forces the liver ventrad from its normal location. Histological and electro...